ACUTE DIETARY PCPA TREATMENT DECREASES THE K(D) OF BRAIN [H-3] 5-HT BINDING IN RAINBOW-TROUT, ONCORHYNCHUS-MYKISS, FED A HIGH-CARBOHYDRATE DIET

Two experiments were conducted to determine the effect of dietary PCPA on brain [H-3]5-HT binding in rainbow trout. [H-3]5-HT binding was quantitatively similar to that observed in mammalian species. Dietary treatment with PCPA had no effect on the B(max) of [H-3]5-HT binding in either experiment while the K(D) was decreased in Experiment 1. These results demonstrate that [H-3]5-HT binding affinity is increased following short term inhibition of 5-HT synthesis by PCPA in rainbow trout.