GENE AMPLIFICATIONS IN ADVANCED-STAGE HUMAN PROSTATE-CANCER

被引：32

作者：

FOURNIER, G

LATIL, A

AMET, Y

ABALAIN, JH

VOLANT, A

MANGIN, P

FLOCH, HH

LIDEREAU, R

机构：

[1] CTR RENE HUGUENIN,SERV ONCOVIROL,ST CLOUD,FRANCE

[2] HOP MORVAN,SERV ANATOMOPATHOL,BREST,FRANCE

[3] HOP MORVAN,SERV BIOCHIM & BIOL MOLEC,BREST,FRANCE

来源：

UROLOGICAL RESEARCH | 1995年 / 22卷 / 06期

关键词：

PROSTATE CARCINOMA; PROSTATIC NEOPLASMS; GENE AMPLIFICATIONS; ONCOGENES; ADVANCED-STAGE DISEASE;

D O I：

10.1007/BF00296872

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Gene amplification is a model of proto-oncogene alterations occasionally observed in human tumors. This amplification can, in some cases, have prognostic value (N-myc in neuroblastoma, c-erbB2 and int-2 in breast cancer, etc.). Amplifications of the proto-oncogenes c-myc, c-erbB2 and int-2 have not yet been report in prostate adenocarcinoma, which, like breast cancer, is hormone dependent. We sought amplifications of these three proto-oncogenes by means of Southern blotting in 15 human prostate adenocarcinoma specimens, most of which were advanced (7 stage C and 6 stage D1 or D2). We confirmed the lack of c-myc and c-erbB2 amplification, regardless of the stage, in contrast to the case of breast cancer. Int-2 amplification was observed in one advanced tumor with bone metastases, out of a total of six stage D tumors. The precise frequency of int-2 amplification and its role in prostate carcinogenesis remain to be determined.

引用

页码：343 / 347

页数：5

共 33 条

[1]

ALI IU, 1989, ONCOGENE, V4, P89

[2]

ANWAR K, 1992, CANCER RES, V52, P5991

[3] AMPLIFIED REGION OF CHROMOSOME BAND-11Q13 IN BREAST AND SQUAMOUS-CELL CARCINOMAS ENCOMPASSES 3 CPG ISLANDS TELOMERIC OF FGF3, INCLUDING THE EXPRESSED GENE EMS1 [J].