INFLUENCE OF DIFFERENT UNSATURATED FATTY-ACIDS ON STABILITY OF RAT ERYTHROCYTE-MEMBRANES

被引：5
|
作者：
ROTH, HP [1 ]
KIRCHGESSNER, M [1 ]
机构：
[1] TECH UNIV MUNICH,INST ERNAHRUNGSPHYSIOL,W-8050 FREISING,GERMANY
来源：
ANNALS OF NUTRITION AND METABOLISM | 1992年 / 36卷 / 02期
关键词：
OSMOTIC FRAGILITY OF ERYTHROCYTES; ESSENTIAL FATTY ACIDS DEFICIENCY; SUPPLEMENTATION OF LINOLEIC ACID AND EICOSAPENTAENOIC ACID;
D O I：
10.1159/000177705
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In rats restrictive feeding of a half-synthetic diet, with coconut fat as the dietary fat, caused an essential fatty acid deficiency with increased osmotic fragility of erythrocytes against hypotonic saline solutions. A 60% replacement of the coconut fat in the basal diet by pure oleic acid (18:1 n-9) or linoleic acid (18:2 n-6) by 0.6% alpha-linolenic acid (18:3 n-3), eicosatrienoic acid (20:3 n-3) or eicosapentaenoic acid (20:5 n-3) led, in the case of linoleic acid and eicosapentaenoic acid, to a significant decrease in the fragility of rat erythrocytes in comparison with the basal diet. The inefficacy of the alpha-linolenic acid treatment is possibly the consequence of a too low dietary supplementation.
引用
收藏
页码：113 / 120
页数：8
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