THE ANTIDOTAL ACTION OF SODIUM-NITRITE AND SODIUM THIOSULFATE AGAINST CYANIDE POISONING

被引：113
作者：
BASKIN, SI [1 ]
HOROWITZ, AM [1 ]
NEALLEY, EW [1 ]
机构：
[1] PHARMAVENE INC,GAITHERSBURG,MD
来源：
JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 32卷 / 04期
关键词：
D O I：
10.1002/j.1552-4604.1992.tb03849.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The combination of sodium thiosulfate and sodium nitrite has been used in the United States since the 1930s as the primary antidote for cyanide intoxication. Although this combination was shown to exhibit much greater efficacy than either ingredient alone, the two compounds could not be used prohylactically because each exhibits a number of side effects. This review discusses the pharmacodynamics, pharmacokinetics, and toxicology of the individual agents, and their combination.
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页码：368 / 375
页数：8
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