BLOCKADE OF SUPEROVULATION IN IMMATURE RAT BY INCREASED BRAIN SEROTONIN

被引：73

作者：

KORDON, C

JAVOY, F

VASSENT, G

GLOWINSKI, J

机构：

[1] Equipe de Recherches Neuroendocrinologiques, C.N.R.S., Groupe de Neuropharmacologie Biochimique, Paris

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1968年 / 4卷 / 02期

关键词：

5-hydroxytryptophan (5-HTP); Brain noradrenalin; Brain serotonin; Control of ovulation; dihydroxyphenylalanine (DOPA); p-chlorophenyl-alanine; α-methyl-p-tyrosine;

D O I：

10.1016/0014-2999(68)90173-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

C.KORDON, F.JAVOY, G.VASSENT and J.GLOWINSKI. Blockade of superovulation in the immature rat by increased brain serotonin, European J. Pharmacol. 4 (1968) 169-174. The MAO inhibitor nialamide blocks ovulation in chorionic gonadotropin-treated immature female rats. Prior blockade of catecholamine synthesis by α-methyl-p-tyrosine (α-MT) does not interfere with this effect, whereas blockade of serotonin synthesis by p-chlorophenyl-alanine (PCPA) antagonises the action of nialamide; 5-hydroxytryptophan (5-HTP), but not dihydroxyphenylalanine (DOPA), inhibits ovulation. Determination of serotonin and noradrenalin brain levels shows that ovulation is only affected by increased brain serotonin. It is concluded that this amine has a specific inhibitory effect on the release of pituitary ovulation hormone. © 1968.

引用

页码：169 / +

页数：1

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