INSULIN ACTION IN PREVIOUSLY DIABETIC RATS RECEIVING GRADED NUMBERS OF ISLETS OF LANGERHANS

被引:4
作者
TOBIN, BW
LEWIS, JT
TOBIN, BL
FINEGOOD, DT
机构
[1] UNIV ALBERTA,SURG MED RES INST,DEPT PHYSIOL,EDMONTON,AB,CANADA
[2] MERCER UNIV,SCH MED,DIV BASIC MED SCI,MACON,GA 31207
[3] MERCER UNIV,SCH MED,DEPT PEDIAT,MACON,GA 31207
[4] UNIV ALBERTA,SURG MED RES INST,DEPT MED,EDMONTON,AB,CANADA
关键词
D O I
10.1097/00007890-199505270-00018
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We characterized insulin sensitivity in islet transplanted rats receiving from 500 to 3000 islets. Male Wistar Furth rats made previously diabetic with streptozotocin (55 mg/kg) were infused intraportally with islets of Langerhans (500 islets: n=8; 1000: n=6; 2000: n=6; 3000: n=5) from syngeneic donors and compared with sham-operated controls (n=7). At four weeks after islet transplantation, fasting blood glucose was not significantly different between groups (500: 5.1+/-0.3; 1000: 4.8+/-0.3; 2000: 5.1+/-0.3; 3000: 4.6+/-0.1; control: 4.7+/-0.2 mM; P = 0.6146), and fasting plasma insulin was also not different (P=0.28), The acute insulin response to glucose (0.3 g/kg i.v.) was correlated with islet equivalent mass (r=0.63, P=0.004; transplant rats only); islet transplant animals presented a range of acute insulin secretion from 3 to 90% of control values. Insulin action was measured in vivo in fasted, conscious animals during a hyperinsulinemic-euglycemic glucose clamp with insulin infused at 29 and 72 nmol/ kg/min. Despite a wide range of islet mass and insulin secretory capacity, there was no significant difference in the glucose infusion rate between islet groups at either insulin level (P=0.8211, P=0.8021). There was also no difference in the glucose infusion rate normalized to the prevailing insulin level (P=0.1638, P=0.2302). Thus, our results demonstrate that the islet transplanted rat is consistent with other animal studies and human studies illustrating that a diminished insulin secretion does not necessarily precipitate insulin resistance.
引用
收藏
页码:1464 / 1469
页数:6
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