INFLUENCE OF NOCLOPROST ON THE VASCULAR-RESPONSES TO VARIOUS STIMULI IN THE ISOLATED PERFUSED RABBIT KIDNEY

被引：0

作者：

ERCAN, ZS ^{[1
]}

TURKER, R ^{[1
]}

机构：

[1] UNIV ANKARA,FAC MED,DEPT PHARMACOL,ANKARA,TURKEY

来源：

EXPERIENTIA | 1991年 / 47卷 / 01期

关键词：

NOCLOPROST; RABBIT KIDNEY; ANGIOTENSIN-II; NORADRENALINE; SYMPATHETIC STIMULATION;

D O I：

10.1007/BF02041256

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nocloprost, a new synthetic prostanoid, elicited a vasodilator action when given through the renal artery of the isolated perfused rabbit kidney. Lower concentrations of the compound inhibited the pressor response to sympathetic stimulation or to angiotensin II, but potentiated the pressor effect of exogenous noradrenaline. These results were taken as an evidence that nocloprost prevents the release of neurotransmitter by a presynaptic mechanism.

引用

页码：69 / 70

页数：2

共 7 条

[1]

ERCAN ZS, 1975, ARCH INT PHYSIOL BIO, V83, P799

[2] COMPARISON OF EFFECTS OF PROSTAGLANDINS E1, E2 AND F 2 ALPHA ON SYMPATHETICALLY STIMULATED RABBIT HEART [J].

HEDQVIST, P ;

WENNMALM, A .

ACTA PHYSIOLOGICA SCANDINAVICA, 1971, 83 (02) :156-+

[3]

LOGE O, 1984, NOV KYOT C PROST

[4] PGI2 INHIBITS ISCHEMIA-INDUCED PLATELET ACTIVATION AND PREVENTS MYOCARDIAL DAMAGE BY INHIBITION OF CATECHOLAMINE RELEASE FROM ADRENERGIC-NERVE TERMINALS - EVIDENCE FOR CAMP AS COMMON DENOMINATOR [J].

SCHROR, K ;

ADDICKS, K ;

DARIUS, H ;

OHLENDORF, R ;

ROSEN, P .

THROMBOSIS RESEARCH, 1981, 21 (1-2) :175-180

[5] ILOPROST PRESERVES KIDNEY-FUNCTION AGAINST ANOXIA [J].

TURKER, RK ;

DEMIREL, E ;

ERCAN, ZS .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1988, 31 (01) :45-52

[6]

TURKER RK, 1989, PROSTAGLANDINS CLIN, P205

[7] THE EFFECTS OF NOCLOPROST, NILEPROST, ILOPROST AND (15 S)-15-METHYL-PGE2 ON GASTRIC-MUCOSAL DAMAGE INDUCED BY STRESS, INDOMETHACIN AND ETHANOL [J].

ZENGIL, H ;

ERCAN, ZS ;

ONUK, E ;

TURKER, RK .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1990, 40 (01) :13-16

← 1 →