SUBCUTANEOUS IMPLANTATION METHOD FOR CHRONIC GLUCOCORTICOID REPLACEMENT THERAPY

被引：193

作者：

MEYER, JS ^{[1
]}

MICCO, DJ ^{[1
]}

STEPHENSON, BS ^{[1
]}

KREY, LC ^{[1
]}

MCEWEN, BS ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,NEW YORK,NY 10021

来源：

PHYSIOLOGY & BEHAVIOR | 1979年 / 22卷 / 05期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Brain corticosterone; Dexamethasone; Glucocorticoid replacement; Radioimmunoassay; Serum corticosterone;

D O I：

10.1016/0031-9384(79)90330-5

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

A procedure is described for replacing glucocorticoids by subcutaneous implantation of pellets formed from molten corticosterone and cholesterol. Hormone dose is controlled by varying the ratio of these two substances in the pellet. The method produces stable blood and brain corticosterone levels in the physiological range within 3 days and is shown to reinstate normal brain glycerolphosphate dehydrogenase activity in previously adrenalectomized rats. The procedure appears to be well-suited to long-term psycho- and neuro-endocrine studies. © 1979.

引用

页码：867 / 870

页数：4

共 8 条

[1]

DEVELLIS J, 1968, J NEUROCHEM, V15, P1061

[2] PASSAGE OF STEROIDS THROUGH SILICONE RUBBER [J].