DNA CROSS-LINKING BY INTERMEDIATES IN THE MITOMYCIN ACTIVATION CASCADE

被引：39

作者：

CERA, C ^{[1
]}

EGBERTSON, M ^{[1
]}

TENG, SP ^{[1
]}

CROTHERS, DM ^{[1
]}

DANISHEFSKY, SJ ^{[1
]}

机构：

[1] YALE UNIV,DEPT CHEM,NEW HAVEN,CT 06511

来源：

BIOCHEMISTRY | 1989年 / 28卷 / 13期

关键词：

D O I：

10.1021/bi00439a049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：5665 / 5669

页数：5

共 17 条

[1]

ANDREWS PA, 1986, J AM CHEM SOC, V108, P4158, DOI 10.1021/ja00274a052

[2] ON THE CHARACTERIZATION OF INTERMEDIATES IN THE MITOMYCIN ACTIVATION CASCADE - A PRACTICAL SYNTHESIS OF AN AZIRIDINOMITOSENE [J].

DANISHEFSKY, SJ ;

EGBERTSON, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (15) :4648-4650

[3] MODELING OF THE ELECTROPHILIC ACTIVATION OF MITOMYCINS - CHEMICAL EVIDENCE FOR THE INTERMEDIACY OF A MITOSENE SEMIQUINONE AS THE ACTIVE ELECTROPHILE [J].

EGBERTSON, M ;

DANISHEFSKY, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (07) :2204-2205

[4]

HATA T, 1956, J ANTIBIOT, V9, P141

[5] REDUCTIVE ACTIVATION OF MITOMYCIN-C [J].

HOEY, BM ;

BUTLER, J ;

SWALLOW, AJ .

BIOCHEMISTRY, 1988, 27 (07) :2608-2614

[6] STUDIES ON MODE OF ACTION OF MITOMYCIN ANTIBIOTICS - REVERSIBLE CONVERSION OF MITOMYCIN-C INTO SODIUM 7-AMINOMITOSANE-9A-SULFONATE [J].

HORNEMANN, U ;

HO, YK ;

MACKEY, JK ;

SRIVASTAVA, SC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (22) :7069-7074

[7] MITOMYCINS + PORFIROMYCIN - CHEMICAL MECHANISM OF ACTIVATION + CROSS-LINKING OF DNA [J].

IYER, VN ;

SZYBALSKI, W .

SCIENCE, 1964, 145 (362) :55-&

[8] MECHANISTIC STUDIES ON THE MODE OF REACTION OF MITOMYCIN-C UNDER CATALYTIC AND ELECTROCHEMICAL REDUCTIVE CONDITIONS [J].

KOHN, H ;

ZEIN, N ;

LIN, XQ ;

DING, JQ ;

KADISH, KM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (06) :1833-1840

[9] HYDROXYL RADICAL PRODUCTION BY FREE AND DNA-BOUND AMINOQUINONE ANTIBIOTICS AND ITS ROLE IN DNA-DEGRADATION - ELECTRON-SPIN RESONANCE DETECTION OF HYDROXYL RADICALS BY SPIN TRAPPING .16. [J].

LOWN, JW ;

SIM, SK ;

CHEN, HH .

CANADIAN JOURNAL OF BIOCHEMISTRY, 1978, 56 (11) :1042-1047

[10] STUDIES RELATED TO ANTITUMOR ANTIBIOTICS .5. REACTIONS OF MITOMYCIN-C WITH DNA EXAMINED BY ETHIDIUM FLUORESCENCE ASSAY [J].

LOWN, JW ;

BEGLEITER, A ;

JOHNSON, D ;

MORGAN, AR .

CANADIAN JOURNAL OF BIOCHEMISTRY, 1976, 54 (02) :110-119

← 1 2 →