CHIRAL HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC STATIONARY PHASES .1. SEPARATION OF THE ENANTIOMERS OF SULFOXIDES, AMINES, AMINO-ACIDS, ALCOHOLS, HYDROXY-ACIDS, LACTONES, AND MERCAPTANS

被引:196
作者
PIRKLE, WH
HOUSE, DW
机构
[1] Roger Adams Laboratory, School of Chemical Sciences, University of Illinois, Urbana
关键词
D O I
10.1021/jo01326a014
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A silica gel bonded chiral fluoro alcoholic stationary phase has been prepared for the direct liquid chromatographic separation of the enantiomers of a wide assortment of solutes. The chiral fluoro alcohol utilized was selected on the basis of a rationally devised chiral recognition model that accounts for the origins of the observed separations and elution orders of the various enantiomers. More than 50 such resolutions are presented for sulfoxides, lactones, and derivatives of amines, amino acids, amino alcohols, alcohols, thiols, and hydroxy acids. © 1979, American Chemical Society. All rights reserved.
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页码:1957 / 1960
页数:4
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