EFFECT OF VITAMIN-B-6 DEFICIENCY ON THE EXPRESSION OF GLYCOGEN-PHOSPHORYLASE MESSENGER-RNA IN RAT-LIVER AND SKELETAL-MUSCLE

被引：20

作者：

OKA, T

KOMORI, N

KUWAHATA, M

SUZUKI, I

OKADA, M

NATORI, Y

机构：

[1] KUMAMOTO WOMENS UNIV,DEPT FOOD & NUTR,KUMAMOTO,KUMAMOTO 862,JAPAN

[2] NARUTO UNIV EDUC,FAC HLTH & LIVING SCI,NARUTO,TOKUSHIMA 772,JAPAN

来源：

EXPERIENTIA | 1994年 / 50卷 / 02期

关键词：

VITAMIN-B-6; GLYCOGEN PHOSPHORYLASE MESSENGER-RNA; RAT LIVER AND MUSCLE;

D O I：

10.1007/BF01984949

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of vitamin B-6 deficiency on the expression of glycogen phosphorylase mRNA in rat liver and skeletal muscle was investigated. The level of phosphorylase mRNA in the muscle of vitamin B-6-deficient rats was reduced to 40% of that in the control rats. By contrast, the phosphorylase mRNA level was increased 5-fold in the liver of the deficient animals. It was also found that the expression of the beta-actin gene, generally regarded as a 'housekeeping' gene, was unaffected by B-6 deficiency in the muscle but was enhanced in the liver of the deficient animals. These observations suggest that vitamin B-6 may modulate the transcriptional activation of the phosphorylase gene in a tissue-specific manner.

引用

页码：127 / 129

页数：3

共 18 条

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[2]

ALLGOOD VE, 1990, J BIOL CHEM, V265, P12424

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