M2e-Based Universal Influenza A Vaccines

被引：145

作者：

Deng, Lei ^{[1
,2
]}

Cho, Ki Joon ^{[1
,2
]}

Fiers, Walter ^{[1
,2
]}

Saelens, Xavier ^{[1
,2
]}

机构：

[1] Univ Ghent VIB, Inflammat Res Ctr, Technol Pk 927, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, Technol Pk 927, B-9052 Ghent, Belgium

来源：

VACCINES | 2015年 / 3卷 / 01期

关键词：

matrix protein 2; influenza; vaccines;

D O I：

10.3390/vaccines3010105

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The successful isolation of a human influenza virus in 1933 was soon followed by the first attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective method to prevent human influenza disease. However, licensed influenza vaccines offer protection against antigenically matching viruses, and the composition of these vaccines needs to be updated nearly every year. Vaccines that target conserved epitopes of influenza viruses would in principle not require such updating and would probably have a considerable positive impact on global human health in case of a pandemic outbreak. The extracellular domain of Matrix 2 (M2e) protein is an evolutionarily conserved region in influenza A viruses and a promising epitope for designing a universal influenza vaccine. Here we review the seminal and recent studies that focused on M2e as a vaccine antigen. We address the mechanism of action and the clinical development of M2e-vaccines. Finally, we try to foresee how M2e-based vaccines could be implemented clinically in the future.

引用

页码：105 / 136

页数：32

共 146 条

[1] Tandem repeats of the extracellular domain of Matrix 2 influenza protein exposed in Brucella lumazine synthase decameric carrier molecule induce protection in mice [J].