THE SYNTHESIS AND ANTIVIRAL ACTIVITY OF SOME 4'-THIO-2'-DEOXY NUCLEOSIDE ANALOGS

被引：160

作者：

DYSON, MR ^{[1
]}

COE, PL ^{[1
]}

WALKER, RT ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 09期

关键词：

D O I：

10.1021/jm00113a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Starting from benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside (4), the following 2'-deoxy nucleoside analogues have been synthesized: 4'-thiothymidine (8), 3'-azido-4'-thio-deoxythymidine (10), and (E)-5-(2-bromovinyl)-4'-thio-2'-deoxyuridine (22). The first compound is toxic, the second is not toxic nor has detectable biological activity, and the third is not toxic and has significant activity against some herpesviruses.

引用

页码：2782 / 2786

页数：5

共 17 条

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