Caffeic acid phenethyl ester as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads

被引：20
作者：
Akyol, Sumeyya [1 ,2 ]
Akbas, Ali [2 ]
Butun, Ilknur [2 ]
Toktas, Muhsin [3 ]
Ozyurt, Huseyin [2 ]
Sahin, Semsettin [2 ]
Akyol, Omer [4 ]
机构：
[1] Turgut Ozal Univ, Fac Med, Dept Med Biol, Ankara, Turkey
[2] Gaziosmanpasa Univ, Fac Med, Dept Biochem, Tokat, Turkey
[3] Turgut Ozal Univ, Fac Med, Dept Anat, Ankara, Turkey
[4] Hacettepe Univ, Fac Med, Dept Biochem, TR-06100 Ankara, Turkey
来源：
JOURNAL OF INTERCULTURAL ETHNOPHARMACOLOGY | 2015年 / 4卷 / 02期
关键词：
Caffeic acid phenethyl ester; gonads; ovary; oxidative damage; protection; testis;
D O I：
10.5455/jice.20150402062823
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In recent years, the studies on the roles of caffeic acid phenethyl ester (CAPE) in several disease models and cell cultures are tremendously growing. It is such a great molecule that was used by ancient times to ameliorate some diseases and nowadays, it is used by modern medicine to test the effectiveness. In this mini-review article, the protection capability of CAPE, as a liposoluble antioxidant and a potent nuclear factor kappa B inhibitor, on oxidative and non-oxidative ovary, and testis damages has been summarized. In view of our laboratory findings/experience and those reported in the hitherto literature, we suggest that CAPE possesses protective effects for pathologies of the reproductive organs induced by untoward effects of harmful molecules such as free oxygen radicals, pesticides, methotrexate, and MK-801 (dizocilpine).
引用
收藏
页码：187 / 191
页数：5
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