IMPROVED PROCEDURE FOR N-FORMYLATION OF AMINES TO FORMAMIDES USING FORMIC-ACID, OXALYL CHLORIDE AND IMIDAZOLE

被引：0
作者：
KITAGAWA, T
ITO, J
TSUTSUI, C
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 09期
关键词：
FORMYLATION; N-FORMYLIMIDAZOLE; IMIDAZOLE; FORMAMIDE; N; N'-CARBANYLDIIMIDAZOLE; OXALYL CHLORIDE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The reaction of imidazole (15) with formyl chloride (14), generated in situ by the action of oxalyl chloride (10) on formic acid (3), afforded N-formylimidazole (7), which is a convenient formylating reagent. This procedure was used to prepare N-formyl derivatives (1) of aliphatic, aromatic and heteroaromatic amines (1) under mild conditions.
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页码：1931 / 1934
页数：4
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