DETECTION OF LOSS OF HETEROZYGOSITY AT THE HUMAN TP53 LOCUS USING A DINUCLEOTIDE REPEAT POLYMORPHISM

被引：245

作者：

JONES, MH ^{[1
]}

NAKAMURA, Y ^{[1
]}

机构：

[1] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,1-37-1 KAMI IKEBUKURO,TOSHIMA KU,TOKYO 170,JAPAN

来源：

GENES CHROMOSOMES & CANCER | 1992年 / 5卷 / 01期

关键词：

D O I：

10.1002/gcc.2870050113

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Loss of heterozygosity at the TP53 locus occurs frequently in many types of cancer and requires polymorphic markers for detection. Several polymorphisms at the TP53 locus have been described previously, and polymerase chain reaction (PCR)-based assays have been developed to detect these polymorphisms. However, these polymorphisms have relatively low levels of heterozygosity and are often uninformative. We report here the detection of loss of heterozygosity at the TP53 locus in various human cancers by using a highly informative dinucleotide repeat polymorphism.

引用

页码：89 / 90

页数：2

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