HYPERTENSIVE DIABETIC RATS - DIFFERENT EFFECTS OF STREPTOZOTOCIN TREATMENT ON BLOOD-PRESSURE IN ADULT SHR AND IN NEONATAL SHR

被引：5
|
作者：
SATO, T [1 ]
NARA, Y [1 ]
KATO, Y [1 ]
YAMORI, Y [1 ]
机构：
[1] SHIMANE MED UNIV,DEPT PATHOL,IZUMO,SHIMANE 693,JAPAN
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE | 1991年 / 13卷 / 05期
关键词：
HYPERTENSION; DIABETES-MELLITUS; ANIMAL MODEL; STREPTOZOTOCIN; SPONTANEOUSLY HYPERTENSIVE RATS;
D O I：
10.3109/10641969109042104
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effect of streptozotocin (STZ) treatment on blood pressure in adult spontaneously hypertensive rats (SHR) was compared with that in neonatal SHR. Three-month-old SHR were intravenously given 10, 30 or 50 mg/kg of STZ. When STZ was given in adult SHR, weight loss, overt hyperglycemia and the reduction of blood pressure occurred dose dependently. Two-day-old pups from SHR were subcutaneously injected with 100 mg/kg of STZ. Neonatal STZ treatment did not attenuate the development of hypertension in SHR. Since neonatally STZ-treated SHR develop mild diabetic symptom with hypertension and develop mild diabetic glomerulosclerosis, they are a good model for studying vascular complications or other disorder relating to the synergism between hypertension and diabetes mellitus.
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页码：981 / 990
页数：10
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