POLYNUCLEOTIDE RECOGNITION AND STRAND SCISSION BY FE-BLEOMYCIN

被引：62
作者：
CARTER, BJ
REDDY, KS
HECHT, SM
机构：
[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901
[2] UNIV VIRGINIA,DEPT BIOL,CHARLOTTESVILLE,VA 22901
来源：
TETRAHEDRON | 1991年 / 47卷 / 14-15期
关键词：
D O I：
10.1016/S0040-4020(01)81781-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The structural basis of sequence-selective DNA recognition by Fe-bleomycin (Fe.BLM) has been studied by the use of BLM congeners in which the two functional domains are separated by spacers of variable length. Fe.bleomycin has also been shown to recognize and cleave RNA, which may constitute a new target of therapeutic importance for BLM.
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页码：2463 / 2474
页数：12
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