SUSTAINED BEHAVIORAL RECOVERY FROM UNILATERAL NIGROSTRIATAL DAMAGE PRODUCED BY THE CONTROLLED RELEASE OF DOPAMINE FROM A SILICONE POLYMER PELLET PLACED INTO THE DENERVATED STRIATUM

被引：45
作者：
BECKER, JB
ROBINSON, TE
BARTON, P
SINTOV, A
SIDEN, R
LEVY, RJ
机构：
[1] UNIV MICHIGAN,DEPT PSYCHOL,ANN ARBOR,MI 48109
[2] UNIV MICHIGAN,NEUROSCI PROGRAM,ANN ARBOR,MI 48109
[3] UNIV MICHIGAN,CS MOTT CHILDRENS HOSP,MED CTR,DIV PEDIAT CARDIOL,ANN ARBOR,MI 48109
来源：
BRAIN RESEARCH | 1990年 / 508卷 / 01期
关键词：
Apomorphine; Controlled release; Dopamine; Parkinson's disease; Rotational behavior;
D O I：
10.1016/0006-8993(90)91117-Y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study was conducted to determine if the behavioral asymmetry associated with unilateral nigrostriatal dopamine (DA) depletion could be alleviated by placing a small DA-releasing silicone polymer matrix pellet into the denervated striatum of rats. Animals that received DA-releasing pellets showed a 50% reduction in apomorphine-induced rotational behavior, and this effect persisted for the 2-month duration of the experiment. The results suggest that the controlled release of DA from an intrastriatal polymer matrix can produce a long-lasting reduction in some of the symptons associated with DA depletion. © 1990.
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页码：60 / 64
页数：5
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