SUSTAINED BEHAVIORAL RECOVERY FROM UNILATERAL NIGROSTRIATAL DAMAGE PRODUCED BY THE CONTROLLED RELEASE OF DOPAMINE FROM A SILICONE POLYMER PELLET PLACED INTO THE DENERVATED STRIATUM

被引：45
作者：
BECKER, JB
ROBINSON, TE
BARTON, P
SINTOV, A
SIDEN, R
LEVY, RJ
机构：
[1] UNIV MICHIGAN,DEPT PSYCHOL,ANN ARBOR,MI 48109
[2] UNIV MICHIGAN,NEUROSCI PROGRAM,ANN ARBOR,MI 48109
[3] UNIV MICHIGAN,CS MOTT CHILDRENS HOSP,MED CTR,DIV PEDIAT CARDIOL,ANN ARBOR,MI 48109
来源：
BRAIN RESEARCH | 1990年 / 508卷 / 01期
关键词：
Apomorphine; Controlled release; Dopamine; Parkinson's disease; Rotational behavior;
D O I：
10.1016/0006-8993(90)91117-Y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study was conducted to determine if the behavioral asymmetry associated with unilateral nigrostriatal dopamine (DA) depletion could be alleviated by placing a small DA-releasing silicone polymer matrix pellet into the denervated striatum of rats. Animals that received DA-releasing pellets showed a 50% reduction in apomorphine-induced rotational behavior, and this effect persisted for the 2-month duration of the experiment. The results suggest that the controlled release of DA from an intrastriatal polymer matrix can produce a long-lasting reduction in some of the symptons associated with DA depletion. © 1990.
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收藏
页码：60 / 64
页数：5
相关论文
共 20 条
[1]   TRANSPLANTATION OF NEURAL TISSUE IN POLYMER CAPSULES [J].
AEBISCHER, P ;
WINN, SR ;
GALLETTI, PM .
BRAIN RESEARCH, 1988, 448 (02) :364-368
[2]   MECHANISMS OF ACTION OF INTRACEREBRAL NEURAL IMPLANTS - STUDIES ON NIGRAL AND STRIATAL GRAFTS TO THE LESIONED STRIATUM [J].
BJORKLUND, A ;
LINDVALL, O ;
ISACSON, O ;
BRUNDIN, P ;
WICTORIN, K ;
STRECKER, RE ;
CLARKE, DJ ;
DUNNETT, SB .
TRENDS IN NEUROSCIENCES, 1987, 10 (12) :509-516
[3]   INVIVO AND INVITRO RELEASE OF MACROMOLECULES FROM POLYMERIC DRUG DELIVERY SYSTEMS [J].
BROWN, LR ;
WEI, CL ;
LANGER, R .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (10) :1181-1185
[4]   NIGROSTRIATAL LESIONS ENHANCE STRIATAL APOMORPHINE-H-3 AND H-3-SPIROPERIDOL BINDING [J].
CREESE, I ;
SNYDER, SH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 56 (03) :277-281
[5]   QUANTIFICATION OF THE DOPAMINE INNERVATION IN ADULT-RAT NEOSTRIATUM [J].
DOUCET, G ;
DESCARRIES, L ;
GARCIA, S .
NEUROSCIENCE, 1986, 19 (02) :427-&
[6]   GRAFTS OF EMBRYONIC SUBSTANTIA NIGRA REINNERVATING THE VENTROLATERAL STRIATUM AMELIORATE SENSORIMOTOR IMPAIRMENTS AND AKINESIA IN RATS WITH 6-OHDA LESIONS OF THE NIGROSTRIATAL PATHWAY [J].
DUNNETT, SB ;
BJORKLUND, A ;
STENEVI, U ;
IVERSEN, SD .
BRAIN RESEARCH, 1981, 229 (01) :209-217
[7]  
DUNNETT SB, 1983, NEURAL TISSUE TRANSP
[8]  
DUNNETT SB, 1982, PROGR BRAIN RES, V55
[9]   NORMALIZATION OF SPIROPERIDOL BINDING IN THE DENERVATED RAT STRIATUM BY HOMOLOGOUS GRAFTS OF SUBSTANTIA NIGRA [J].
FREED, WJ ;
KO, GN ;
NIEHOFF, DL ;
KUHAR, MJ ;
HOFFER, BJ ;
OLSON, L ;
CANNONSPOOR, HE ;
MORIHISA, JM ;
WYATT, RJ .
SCIENCE, 1983, 222 (4626) :937-939
[10]   TRANSPLANTED ADRENAL CHROMAFFIN CELLS IN RAT-BRAIN REDUCE LESION-INDUCED ROTATIONAL BEHAVIOR [J].
FREED, WJ ;
MORIHISA, JM ;
SPOOR, E ;
HOFFER, BJ ;
OLSON, L ;
SEIGER, A ;
WYATT, RJ .
NATURE, 1981, 292 (5821) :351-352
12