Expressions of SEL 1L and C-erbB-2 in Gastric Cancer Tissues and Its Clinical Significance

Objective: To investigate the expressions and clinical significance of human sel-1-like (SEL 1L) gene and oncogene c-erbB-2 in gastric cancer tissue. Methods: SEL 1L and c-erbB-2 expressions in gastric cancer tissues of 96 patients with gastric cancer were detected by immunohistochemical method. Results: The positive expression rate of SEL 1L gene in gastric cancer tissue was 84.4% (81/96), and its expression was significantly associated with the differentiated degree of gastric cancer tissue (P = 0.001), but had no association with the age, gender, tumor size, infiltration depth, lymphatic metastasis and TNM staging (P > 0.05). The positive expression rate of c-erbB-2 was 70.8% (68/96), and its expression was related to the differentiated degree of gastric cancer tissue, infiltration depth, lymphatic metastasis and TNM staging (P = 0.002, P < 0.05) instead of the age, gender and tumor size (P > 0.05). SEL 1L and c-erbB-2 expressions had a significantly positive correlation (r = 0.568, P < 0.01). Conclusion: Both SEL 1L and c-erbB-2 are highly expressed in gastric cancer tissues and their joint detection can be considered as a biomarker for identifying the high-risk patients with gastric cancer.