THE 21-AMINOSTEROID ANTIOXIDANT, U74389F, PREVENTS ESTRADIOL-INDUCED DEPLETION OF HYPOTHALAMIC BETA-ENDORPHIN IN ADULT FEMALE RATS

被引：12

作者：

SCHIPPER, HM ^{[1
]}

DESJARDINS, GC ^{[1
]}

BEAUDET, A ^{[1
]}

BRAWER, JR ^{[1
]}

机构：

[1] MCGILL UNIV, JEWISH GEN HOSP, BLOOMFIELD CTR RES AGING, DEPT NEUROL & NEUROSURG, MONTREAL H3T 1E2, PQ, CANADA

来源：

BRAIN RESEARCH | 1994年 / 652卷 / 01期

基金：

英国医学研究理事会;

关键词：

ESTRADIOL; BETA-ENDORPHIN; 21-AMINOSTEROID; FREE RADICAL; HYPOTHALAMUS;

D O I：

10.1016/0006-8993(94)90332-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A single intramuscular injection of 2 mg estradiol valerate (EV) results in neuronal degeneration and beta-endorphin depletion in the hypothalamic arcuate nucleus of adult female rats. We have hypothesized that peroxidase-positive astrocytes in this brain region oxidize estrogens and catecholestrogens to semiquinone radicals which mediate oxidative neuronal injury. In the present study, dietary administration of the potent antioxidant 21-aminosteroid, U-74389F, completely blocked EV-induced beta-endorphin depletion in the hypothalami of adult female rats. Neither EV nor 21-aminosteroid treatment had any effect on hypothalamic concentrations of neuropeptide Y and Met-enkephalin, confirming that the estradiol lesion is fairly selective for the beta-endorphin cell population. The present findings support the hypothesis that the toxic effect of estradiol on hypothalamic beta-endorphin neurons is mediated by free radicals.

引用

页码：161 / 163

页数：3

共 22 条

[1] FORMATION OF 2-HYDROXYESTROGENS AND 4-HYDROXYESTROGENS BY BRAIN, PITUITARY, AND LIVER OF HUMAN FETUS [J].