MEMBRANE EXPRESSION AND FUNCTION OF COMPLEMENT RECEPTORS CR-1 AND CR3 ON NEUTROPHILS FROM HIV-INFECTED SUBJECTS - MODULATION BY RTNF-ALPHA AND RGM-CSF

被引:8
作者
CAPSONI, F [1 ]
MINONZIO, F [1 ]
COLOMBO, G [1 ]
ONGARI, AM [1 ]
BONARA, P [1 ]
RIZZARDI, GP [1 ]
LAZZARIN, A [1 ]
ZANUSSI, C [1 ]
机构
[1] UNIV MILAN,IST MED INTERNA MALATTIE & IMMUNOPATOL,I-20122 MILAN,ITALY
关键词
D O I
10.1111/j.1365-3083.1992.tb03222.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We evaluated membrane expression and function of complement receptors CR1 and CR3 on neutrophils from 27 HIV-positive (HIV+) subjects (14 in the CDC class III and 13 class IV) as well as their modulation in vitro by recombinant tumour necrosis factor-alpha (rTNF-alpha) and granulocyte-macrophage colony stimulating factor (rGM-CSF). While CR1 was expressed at similar levels on neutrophils from controls and HIV+ subjects. CR3 expression was significantly higher in CDC class IV subjects than in healthy controls. CR1 and CR3 expression was significantly increased after treatment of neutrophils with both cytokines, without differences between controls and HIV+ subjects. Similarly, the superoxide anion (O2-) production in response to C3-coated zymosan (C3zy) was significantly enhanced on neutrophils from CDC class IV subjects when compared with controls. rGM-CSF and rTNF-alpha treatment significantly enhanced the spontaneous as well as C3zy-stimulated O2- production by neutrophils from controls and CDC class III subjects, and induced an upward trend in the CDC class IV group. These results indicate that the neutrophils of HIV+ patients are preactivated in vivo but they also indicate that these cells may correctly respond to a subsequent particulate stimulus as well as to activating cytokines. Our findings suggest that desensitization or functional exhaustion of complement receptors are not implicated in the abnormalities observed on neutrophils from HIV+ patients.
引用
收藏
页码:541 / 546
页数:6
相关论文
共 23 条
[1]   HUMAN-NEUTROPHILS INCREASE EXPRESSION OF C3BI AS WELL AS C3B RECEPTORS UPON ACTIVATION [J].
BERGER, M ;
OSHEA, J ;
CROSS, AS ;
FOLKS, TM ;
CHUSED, TM ;
BROWN, EJ ;
FRANK, MM .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (05) :1566-1571
[2]   BACTERIAL-INFECTION IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME OF CHILDREN [J].
BERNSTEIN, LJ ;
KRIEGER, BZ ;
NOVICK, B ;
SICKLICK, MJ ;
RUBINSTEIN, A .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1985, 4 (05) :472-475
[3]   CHANGE IN EXPRESSION OF FC-GAMMA-RIII (CD16) ON NEUTROPHILS FROM HUMAN IMMUNODEFICIENCY VIRUS-INFECTED INDIVIDUALS [J].
BOROS, P ;
GARDOS, E ;
BEKESI, GJ ;
UNKELESS, JC .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1990, 54 (02) :281-289
[4]  
BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
[5]  
Busch M, 1986, BLOOD S, V68, p122a
[6]   THE ROLE OF CACHECTIN/TNF IN ENDOTOXIC-SHOCK AND CACHEXIA [J].
CERAMI, A ;
BEUTLER, B .
IMMUNOLOGY TODAY, 1988, 9 (01) :28-31
[7]   IMPAIRED NEUTROPHIL FUNCTION IN PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX - A COMPREHENSIVE EVALUATION [J].
ELLIS, M ;
GUPTA, S ;
GALANT, S ;
HAKIM, S ;
VANDEVEN, C ;
TOY, C ;
CAIRO, MS .
JOURNAL OF INFECTIOUS DISEASES, 1988, 158 (06) :1268-1276
[8]   EARLY DEFECT OF PHAGOCYTIC CELL-FUNCTION IN SUBJECTS AT RISK FOR ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].
ESTEVEZ, ME ;
BALLART, IJ ;
DIEZ, RA ;
PLANES, N ;
SCAGLIONE, C ;
SEN, L .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1986, 24 (02) :215-221
[9]  
FEARON DT, 1983, J IMMUNOL, V130, P370
[10]   INFLUENCE OF HIV ANTIGENS ON FUNCTIONAL-ACTIVITY OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH HIV-INFECTION [J].
GABRILOVICH, DI ;
KOZHICH, AT ;
SUVOROVA, ZK ;
IVANOV, VS ;
MOSHNIKOV, SA ;
CHIKIN, LD ;
KOLEZONKOVA, OV ;
POKROVSKY, VV .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1991, 33 (05) :549-552