THE ENDOTHELIUM-DEPENDENT RELAXATION OF HUMAN MIDDLE CEREBRAL-ARTERY - EFFECTS OF ACTIVATED NEUTROPHILS

被引：25

作者：

AKOPOV, SE

GRIGORIAN, MR

GABRIELIAN, ES

机构：

[1] Department of Pharmacology, Yerevan Medical Institute, Yerevan, Armenia, 375025

来源：

EXPERIENTIA | 1992年 / 48卷 / 01期

关键词：

NEUTROPHILS; ENDOTHELIUM; OXYGEN PRODUCTS; REGULATION BY DRUGS;

D O I：

10.1007/BF01923601

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neutrophils, activated by 4-beta-phorbol-12-beta-myristate-13-alpha-acetate, decreased acetylcholine-induced relaxation of strips of human middle cerebral artery precontracted with noradrenaline. This effect was prevented by catalase, but not by superoxide dismutase. Nifedipine, propranolol and, less markedly, captopril reduced the decrease in acetylcholine-induced relaxation. Aspirin and dipyridamole did not reduce it.

引用

页码：34 / 36

页数：3

共 9 条

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[2]

KARAKI H, 1981, ARCH INT PHARMACOD T, V252, P29

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OYAMA Y, 1986, EUR J PHARMACOL, V131, P75

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