NORMAL SERUM IMMUNOGLOBULINS INFLUENCE THE NUMBERS OF BONE-MARROW PRE-B AND B-CELLS

被引：52
|
作者：
SUNDBLAD, A [1 ]
MARCOS, M [1 ]
HUETZ, F [1 ]
FREITAS, A [1 ]
HEUSSER, C [1 ]
PORTNOI, D [1 ]
COUTINHO, A [1 ]
机构：
[1] CIBA GEIGY AG,RES DEPT,CH-4002 BASEL,SWITZERLAND
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 05期
关键词：
D O I：
10.1002/eji.1830210510
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The homeostatic mechanisms controlling B lymphocyte output from bone marrow are not well understood. The present experiments evaluated putative influences of circulating immunoglobulins (Ig) on bone marrow (BM) pre-B and B cell populations. Injections into normal mice of Ig isolated from normal mouse serum, resulted in a dose-dependent and reversible reduction in numbers of BM B lineage cells, in particular of small B220+ surface IgM- cells. Maximal effects were observed upon injection of isologous polyclonal Ig and were independent of mature T cells. These results suggest a feedback modulation of peripheral Ig on cellular activities in BM B lineage compartments, mediated by mechanisms that seem to involve the variable regions of the Ig molecule.
引用
收藏
页码：1155 / 1161
页数：7
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