A NOVEL ENANTIOSELECTIVE SYNTHESIS OF HMG CO-A REDUCTASE INHIBITOR NK-104 AND A RELATED COMPOUND

被引：22

作者：

MINAMI, T ^{[1
]}

HIYAMA, T ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,4-4-1 NISHIOHNUMA,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)60814-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active methyl 6-oxo-3.5-syn-isopropylidenedioxyhexanoate (5) was prepared by enantioselective syn-reduction of beta,delta-diketo ester 2, followed by hydrolysis, protection of the diol moiety and ozonolysis, and was converted into a highly potent HMG Co-A reductase inhibitor NK-104 and an analogue.

引用

页码：7525 / 7526

页数：2

共 8 条

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