PATHOPHYSIOLOGICAL STATUS OF SERUM ANTIOXIDANT, MACRO-MINERALS AND TRACE ELEMENTS IN PATIENTS WITH METABOLIC SYNDROME IN BANGLADESH

被引：1

作者：

Rahman, Mohammad Shahidur ^{[1
]}

Hasan, Kamrul ^{[2
]}

Hussain, Md Saddam ^{[2
]}

Millat, Md Shalahuddin ^{[2
]}

Sen, Niloy ^{[2
]}

Islam, Mohammad Safiqul ^{[2
]}

Sarwar, Md Shahid ^{[2
]}

Noor, Wahiduzzaman ^{[2
]}

Kar, Auditi ^{[2
]}

Uddin, S. M. Naim ^{[3
]}

Yokota, Kazushige ^{[1
]}

机构：

[1] Shimane Univ, Dept Life Sci & Biotechnol, 1060 Nishikawatsu Cho, Matsue, Shimane 6908504, Japan

[2] Noakhali Sci & Technol Univ, Dept Pharm, Noakhali 3814, Bangladesh

[3] Univ Chittagong, Dept Pharm, Chittagong 4331, Bangladesh

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2018年 / 9卷 / 03期

关键词：

Metabolic syndrome; Antioxidant; Trace elements; Macro-minerals; Inter-element relationship;

D O I：

10.13040/IJPSR.0975-8232.9(3).1012-22

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study was undertaken to elucidate the serum antioxidant (Vitamin C), macro - minerals (Ca, Na, and K) and trace elements (Zn, Fe) concentration of in patients with metabolic syndromes. Metabolic syndrome was examined by following the definition developed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII). Serum Vitamin C was estimated by phenyl-hydrazine spectrophotometry method. while Macro-minerals and trace elements were determined under coordination of two methods these was flame atomic absorption spectrometry (FAAS) and graphite furnace. This study found that Vitamin C is lowering significantly (p < 0.05) in patients with metabolic syndrome while compared with control subjects. Analysis of serum trace elements (Zn, Fe) and macro minerals (Ca, Na, K) explored low serum concentrations in examined patients significantly either than control group (P < 0.05). Pearson's correlation analysis revealed negative correlation between blood glucose and Fe, Triglyceride and Zn level were found statistically significant. On the basis of our present study it can be asserted that depletion of Vitamin C, Zn, Fe, Ca, K and Na levels is strongly associated with the metabolic syndrome pathogenesis.

引用

页码：1012 / 1022

页数：11

共 57 条

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