ROLE OF ENDOTHELIAL-DERIVED NITRIC-OXIDE IN NORMAL AND HYPERTENSIVE PULMONARY VASCULATURE

被引：16
作者：
ARCHER, S [1 ]
HAMPL, V [1 ]
MCKENZIE, Z [1 ]
NELSON, D [1 ]
HUANG, J [1 ]
SCHULTZ, PJ [1 ]
WEIR, EK [1 ]
机构：
[1] UNIV MINNESOTA,DEPT MED,MINNEAPOLIS,MN 55455
来源：
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE | 1994年 / 15卷 / 03期
关键词：
D O I：
10.1055/s-2007-1006361
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The role of EDNO in the PHT has been primarily evaluated in animals, with few human studies. Most research has focused on the chronic hypoxic form of PHT. With these limitations in mind, we conclude that basal pulmonary EDNO synthesis is preserved or increased in PHT. Although this EDNO up-regulation seems to reduce the severity of PHT, its relative importance among other modulating factors remains to be established.
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页码：179 / 189
页数：11
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