GEPHYRONIC ACID, A NOVEL INHIBITOR OF EUKARYOTIC PROTEIN-SYNTHESIS FROM ARCHANGIUM-GEPHYRA (MYXOBACTERIA) - PRODUCTION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES, AND MECHANISM OF ACTION

被引：31

作者：

SASSE, F ^{[1
]}

STEINMETZ, H ^{[1
]}

HOFLE, G ^{[1
]}

REICHENBACH, H ^{[1
]}

机构：

[1] GESELL BIOTECHNOL FORSCH MBH,NATURSTOFFBIOL ABT,D-38124 BRAUNSCHWEIG,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 01期

关键词：

D O I：

10.7164/antibiotics.48.21

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new antibiotic compound, gephyronic acid was isolated from the culture broth of the myxobacterium, Archangium gephyra strain Ar 3895. Up to 3 mg/liter was produced during the logarithmic and stationary growth phase. The compound is an aliphatic acid, which tends to form a hemiacetal. Both forms inhibited growth of yeasts and molds (MIC 1 similar to 25 mu g/ml) and had a cytostatic effect on mammalian cell cultures (IC50 10 similar to 60 ng/ml). Gephyronic acid is a specific inhibitor of eukaryotic protein sythesis showing an IC50 of 1 similar to 2 x 10(-7) mol/liter in an in vitro translation assay.

引用

页码：21 / 25

页数：5

共 4 条

[1] ANTIBIOTICS FROM GLIDING BACTERIA .10. THE MYXOVALARGINS, NEW PEPTIDE ANTIBIOTICS FROM MYXOCOCCUS-FULVUS (MYXOBACTERALES) .1. CULTIVATION, ISOLATION, AND SOME CHEMICAL AND BIOLOGICAL PROPERTIES [J].

IRSCHIK, H ;

GERTH, K ;

KEMMER, T ;

STEINMETZ, H ;

REICHENBACH, H .

JOURNAL OF ANTIBIOTICS, 1983, 36 (01) :6-12

[2] ANTIBIOTICS FROM GLIDING BACTERIA - PRODUCTION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF ANGIOLAM-A, A NEW ANTIBIOTIC FROM ANGIOCOCCUS-DISCIFORMIS (MYXOBACTERALES) [J].

KUNZE, B ;

KOHL, W ;

HOFLE, G ;

REICHENBACH, H .

JOURNAL OF ANTIBIOTICS, 1985, 38 (12) :1649-1654

[3] ISOLATION AND IDENTIFICATION OF ALTHIOMYCIN FROM CYSTOBACTER-FUSCUS (MYXOBACTERALES) [J].

KUNZE, B ;

REICHENBACH, H ;

AUGUSTINIAK, H ;

HOFLE, G .

JOURNAL OF ANTIBIOTICS, 1982, 35 (05) :635-636

[4]

STEINMETZ H, UNPUB LIEBIGS ANN CH

← 1 →