EFFECT OF A NEW CALCIUM-ANTAGONIST ON HEMODYNAMICS AT REST AND EXERCISE LOADING IN PATIENTS WITH ESSENTIAL-HYPERTENSION

被引：0

作者：

SUZUKI, S ^{[1
]}

HASHIMOTO, T ^{[1
]}

KUSANO, S ^{[1
]}

KAPUKU, K ^{[1
]}

UTSUNOMIYA, T ^{[1
]}

YANO, K ^{[1
]}

机构：

[1] NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 3,NAGASAKI 852,JAPAN

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1993年 / 43-2卷 / 11期

关键词：

ANTIHYPERTENSIVES; CAS; 86780-90-7; HYPERTENSION; ESSENTIAL; (PLUS-OR-MINUS)-METHYL 2-OXOPROPYL 1,4-DIHYDRO 2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE; MPC-1304;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

MPC-1304 ((+/-)-methyl 2-oxopropyl 1,4-dihydro 2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate, CAS 86780-90-7), a new calcium antagonist, was orally administered to 10 outpatients with mild essential hypertension. It was observed that MPC-1304 inhibited elevations of blood pressure both at rest and under exercise loading without any adverse hemodynamic effects. The findings obtained indicated that MPC-1304 would be clinically useful in the treatment of hypertensive patients undergoing therapy while continuing normal everyday activities including physical exertion.

引用

页码：1152 / 1156

页数：5

共 10 条

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