STEROID-RECEPTOR ENHANCEMENT BY NATURAL INTERFERON-BETA IN ADVANCED BREAST-CANCER

被引：29
|
作者：
SICA, G
IACOPINO, F
LAMA, G
AMADORI, D
BARONI, M
SARDO, FL
MALACARNE, P
MARCHETTI, P
PELLEGRINI, A
ZANIBONI, A
DELLACUNA, GR
机构：
[1] UNIV LAQUILA, DIPARTIMENTO MED SPERIMENTALE, I-67100 LAQUILA, ITALY
[2] UNIV ROME LA SAPIENZA, DIPARTIMENTO MED SPERIMENTALE, ONCOL CLIN, I-00185 ROME, ITALY
[3] SPEDALI CIVIL BRESCIA, SEZ ONCOL, BRESCIA, ITALY
[4] FDN CLIN LAVORO, DIV ONCOL, PAVIA, ITALY
[5] OSPED G MORGAGNI L PIERANTONI, FORLI, ITALY
[6] IST ONCOL M ASCOLI, PALERMO, ITALY
来源：
EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 03期
关键词：
D O I：
10.1016/0959-8049(93)90378-S
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In the current study we investigated the effect of two different doses of natural interferon-beta (IFN-beta) on steroid hormone receptors in 45 patients with advanced breast cancer. IFN-beta seems to regulate the receptor mechanisms, inducing in cutaneous metastases an increase of oestrogen and progesterone receptors. Moreover, using IFN-beta and tamoxifen as a combined therapy in 23 receptor-positive patients, no negative interference of the two drugs was observed and no relevant side-effects due to the treatment were noticed. The moduation of steroid receptor content by IFN-beta in advanced breast cancer might represent an interesting way to ameliorate the clinical responsiveness to anti-oestrogens.
引用
收藏
页码：329 / 333
页数：5
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