IMMUNOHISTOCHEMICAL DEMONSTRATION OF ALPHAB-CRYSTALLIN IN HAMARTOMAS OF TUBEROUS SCLEROSIS

被引：0
作者：
IWAKI, T [1 ]
TATEISHI, J [1 ]
机构：
[1] KYUSHU UNIV,FAC MED,INST NEUROL,DEPT NEUROPATHOL,FUKUOKA 812,JAPAN
来源：
AMERICAN JOURNAL OF PATHOLOGY | 1991年 / 139卷 / 06期
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D O I：
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中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of alpha-B-crystallin. Positive immunoreactions were detected in the harmartomas of various organs. Abnormal expression of alpha-B-crystallin in the hamartomas in conjunction with the alpha-B-crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of alpha-B-crystallin gene expression.
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页码：1303 / 1308
页数：6
相关论文
共 30 条
  • [1] ALPHA-B SUBUNIT OF LENS-SPECIFIC PROTEIN ALPHA-CRYSTALLIN IS PRESENT IN OTHER OCULAR AND NON-OCULAR TISSUES
    BHAT, SP
    NAGINENI, CN
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 158 (01) : 319 - 325
  • [2] Bourneville DM, 1880, ARCH NEUROL-CHICAGO, V1, P81
  • [3] GENETIC-LINKAGE ANALYSIS AND HOMOLOGY RELATIONSHIPS OF GENES LOCATED ON HUMAN CHROMOSOME-11Q
    CHARMLEY, P
    NGUYEN, J
    WEI, S
    GATTI, RA
    [J]. GENOMICS, 1991, 10 (03) : 608 - 617
  • [4] CLARK RD, 1991, ANN NY ACAD SCI, V615, P243
  • [5] CONNOR JM, 1991, ANN NY ACAD SCI, V615, P265
  • [6] EXPRESSION OF THE MURINE ALPHA-B-CRYSTALLIN GENE IS NOT RESTRICTED TO THE LENS
    DUBIN, RA
    WAWROUSEK, EF
    PIATIGORSKY, J
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (03) : 1083 - 1091
  • [7] FRYER AE, 1987, LANCET, V1, P659
  • [8] LOCALIZATION OF AN ATAXIA-TELANGIECTASIA GENE TO CHROMOSOME 11Q22-23
    GATTI, RA
    BERKEL, I
    BODER, E
    BRAEDT, G
    CHARMLEY, P
    CONCANNON, P
    ERSOY, F
    FOROUD, T
    JASPERS, NGJ
    LANGE, K
    LATHROP, GM
    LEPPERT, M
    NAKAMURA, Y
    OCONNELL, P
    PATERSON, M
    SALSER, W
    SANAL, O
    SILVER, J
    SPARKES, RS
    SUSI, E
    WEEKS, DE
    WEI, S
    WHITE, R
    YODER, F
    [J]. NATURE, 1988, 336 (6199) : 577 - 580
  • [9] GROWTH-KINETICS, CELL-SHAPE, AND THE CYTOSKELETON OF PRIMARY ASTROCYTE CULTURES
    GOLDMAN, JE
    CHIU, FC
    [J]. JOURNAL OF NEUROCHEMISTRY, 1984, 42 (01) : 175 - 184
  • [10] USE OF AVIDIN-BIOTIN INTERACTION IN IMMUNOENZYMATIC TECHNIQUES
    GUESDON, JL
    TERNYNCK, T
    AVRAMEAS, S
    [J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1979, 27 (08) : 1131 - 1139
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