共 21 条
ANDRO-IVF: a novel protocol for poor responders to IVF controlled ovarian stimulation
被引:10
作者:

Bercaire, Ludmila
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h-index: 0
机构:
Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil

Nogueira, Sara M. B.
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h-index: 0
机构:
Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil

Lima, Priscila C. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil

Alves, Vanessa R.
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil

Donadio, Nilka
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil

Dzik, Artur
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil

Cavagna, Mario
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil

Fanchin, Renato
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Foch, IVF Ctr, Suresnes, France Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil
机构:
[1] Hosp Perola Byington, IVF Ctr, Sao Paulo, SP, Brazil
[2] Hosp Foch, IVF Ctr, Suresnes, France
来源:
JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA
|
2018年
/
22卷
/
01期
关键词:
Fertilization in vitro;
androgens;
ovulation induction;
oocyte retrieval;
fertility agents;
primary ovarian insufficiency;
D O I:
10.5935/1518-0557.20180011
中图分类号:
R71 [妇产科学];
学科分类号:
100211 ;
摘要:
Objective: This study aimed to assess a novel protocol designed to improve poor ovarian response through intra-ovarian androgenization. The endpoints were: number of oocytes and mature oocytes retrieved, fertilization, cancellation and pregnancy rates. Methods: This prospective crossover study enrolled poor responders from previous ovarian stimulation cycles submitted to a novel protocol called ANDRO-IVF. The protocol included pretreatment with transdermal AndroGel(r) (Besins) 25 mg, oral letrozole 2.5 mg and subcutaneous hCG 2500 IU; cycle control was performed with estradiol valerate and micronized progesterone; ovarian stimulation was attained with gonadotropins FSH/LH 450 IU, GnRH antagonist and hCG 5000 IU. Results: Fourteen poor responders were enrolled. One patient did not meet the inclusion criteria. Thirteen patients previously summited to the standard protocol were offered the ANDRO-IVF Protocol.-Standard Protocol: Mean age: 35.30 years; cancellation rate: 61.53%; mean number of MII oocytes retrieved per patient: 1.8; fertilization rate: 33.33%. Only two patients had embryo transfers, and none got pregnant.-ANDRO-IVF Protocol: Mean age: 35.83 years; cancellation rate: 7.69%; mean number of oocytes retrieved per patient: 5.58, MII oocytes: 3.91. ICSI was performed in 84.61% of the patients and a mean of 1.5 embryos were transferred per patient. Fertilization rate: 62.5%; cumulative pregnancy rate: 16.66%; mean duration of stimulation: 9.77 days. Conclusion: ANDRO-IVF allows intra-ovarian androgenization by increasing serum and intra-follicular androgen levels and preventing androgen aromatization. This protocol apparently improved clinical outcomes of poor responders in parameters such as number of oocytes retrieved and clinical pregnancy rates. Further randomized controlled trials are needed to confirm these findings.
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页码:52 / 55
页数:4
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h-index: 0
机构:
Univ Autonoma Barcelona, E-08193 Barcelona, Spain Hosp del Mar, Dept Obstet & Gynecol, Barcelona, Spain

Sola, Ivan
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机构:
IIB St Pau, Inst Biomed Res, Iberoamer Cochrane Ctr, Barcelona, Spain Hosp del Mar, Dept Obstet & Gynecol, Barcelona, Spain

Fabregues, Francisco
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机构:
Univ Barcelona, Fac Med, Inst Invest Biomed August Pi Sunyer IDIBAPS, Hosp Clin Barcelona,Inst Clin Gynesol Obstet & Ne, Barcelona 7, Spain Hosp del Mar, Dept Obstet & Gynecol, Barcelona, Spain

Carreras, Ramon
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机构:
Hosp del Mar, Dept Obstet & Gynecol, Barcelona, Spain Hosp del Mar, Dept Obstet & Gynecol, Barcelona, Spain

Checa, Miguel A.
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机构:
Hosp del Mar, Dept Obstet & Gynecol, Barcelona, Spain
Ctr Infertil & Reprod Humana, Barcelona, Spain Hosp del Mar, Dept Obstet & Gynecol, Barcelona, Spain