Expression of Caveolin-3 in the Myelin Sheath of Peripheral Nerve

被引：0

作者：

Kwon, Bum Sun ^{[1
]}

机构：

[1] Dongguk Univ, Coll Med, Dept Rehabil Med, Seoul, South Korea

来源：

ANNALS OF REHABILITATION MEDICINE-ARM | 2006年 / 30卷 / 04期

关键词：

Caveolin-3; Immunocytochemistry; Peripheral nerve; Regeneration;

D O I：

暂无

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

Objective: To exhibit the caveolin-3 immunoreactivities (IRs) in the peripheral nerve, which was previously known to be present only within the muscle and to be a causative agent of myopathy Method: The sciatic nerves of the rat were removed after the perfusion and frozen after cryoprotection by sucrose. The tissue specimens were cut on cryostat and immunostained with anti-caveolin-3 and growth associated protein-43 (GAP-43) antibodies. The sections were observed with a fluorescence microscope. Results: We detected caveolin-3 IRs in myelin sheath of the peripheral nerves, while GAP IRs were detected in the axon. Caveolin-3 IRs were active in the rat of postnatal 1 week, but they were reduced in the rat of postnatal 3 week and disappeared in that of 5 week. Conclusion: We detected caveolin-3 IRs in the myelin sheath of peripheral nerve. Caveolin-3 might play roles in the early myelination of peripheral nerve.

引用

页码：353 / 356

页数：4

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