TRANS-ACPD SELECTIVELY INHIBITS EXCITABILITY OF HIPPOCAMPAL CA1 NEURONS

被引：9
|
作者：
GARASCHUK, OV [1 ]
KOVALCHUK, YN [1 ]
KRISHTAL, OA [1 ]
机构：
[1] AA BOGOMOLETZ PHYSIOL INST, BOGOMOLETZ ST 4, KIEV 252024, UKRAINE, USSR
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 212卷 / 2-3期
关键词：
TRANS-ACPD (TRANS-1-AMINOCYCLOPENTYL-1,3-DICARBOXYLIC ACID); HIPPOCAMPUS; SYNAPTIC TRANSMISSION;
D O I：
10.1016/0014-2999(92)90351-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The selective agonist of metabotropic glutamate receptors, t-ACPD (trans-1-aminocyclopentyl-1,3-dicarboxylic acid) (100-250-mu-M), reversibly inhibited extracellularly recorded EPSP (excitatory postsynaptic potentials) in the CA1 layer of rat hippocampus. This effect was accompanied by depression of electrical excitability of CA1 neurons as revealed by their antidromic stimulation. The excitability of CA3 neurons remained uneffected. Peculiarly, excitatory postsynaptic currents recorded in voltage clamped, internally perfused CA1 cells remained unaltered. Selective depolarization of CA1 neurons may account for the phenomena described.
引用
收藏
页码：305 / 306
页数：2
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