NEW N-ALKYL DERIVATIVES OF AMPHOTERICIN-B - SYNTHESIS AND BIOLOGICAL PROPERTIES

被引：20

作者：

CZERWINSKI, A ^{[1
]}

KONIG, WA ^{[1
]}

ZIENIAWA, T ^{[1
]}

SOWINSKI, P ^{[1
]}

SINNWELL, V ^{[1
]}

MILEWSKI, S ^{[1
]}

BOROWSKI, E ^{[1
]}

机构：

[1] UNIV HAMBURG,INST ORGAN CHEM,W-2000 HAMBURG 13,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 09期

关键词：

D O I：

10.7164/antibiotics.44.979

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The synthesis of new N-alkyl amphotericin B derivatives obtained in the Michael addition reaction of the antibiotic with N-substituted maleimides is described and in vitro biological data are presented.

引用

页码：979 / 984

页数：6

共 15 条

[1] PREPARATION OF A POSITIVELY CHARGED MALEIMIDE AND ITS APPLICATION TO THE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF THE TRYPTIC PEPTIDES OF LYSOZYME [J].

BRANTLEY, RK ;

HAEFFNERGORMLEY, L ;

WETLAUFER, DB .

JOURNAL OF CHROMATOGRAPHY, 1984, 295 (01) :220-225

[2] QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS IN AMPHOTERICIN-B DERIVATIVES [J].

CHERON, M ;

CYBULSKA, B ;

MAZERSKI, J ;

GRZYBOWSKA, J ;

CZERWINSKI, A ;

BOROWSKI, E .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (05) :827-836

[3] AMIDES OF POLYENE MACROLIDE AUREOFACIN SYNTHESIS AND BIOLOGICAL PROPERTIES [J].

CZERWINSKI, A ;

KONIG, WA ;

SOWINSKI, P ;

BOROWSKI, E .

JOURNAL OF ANTIBIOTICS, 1987, 40 (07) :1023-1027

[4] AMPHOTERICIN-B 2-MORPHOLINOETHYLAMIDE DIASPARTATE, A NEW WATER-SOLUBLE DERIVATIVE OF THE ANTIBIOTIC-SYNTHESIS AND BIOLOGICAL PROPERTIES [J].

CZERWINSKI, A ;

ZIENIAWA, T ;

BOROWSKI, E ;

MICOSSI, LG .

JOURNAL OF ANTIBIOTICS, 1990, 43 (06) :680-683

[5] N-DIMETHYLAMINOACYL DERIVATIVES OF POLYENE MACROLIDE ANTIBIOTICS [J].

CZERWINSKI, A ;

GRZYBOWSKA, J ;

BOROWSKI, E .

JOURNAL OF ANTIBIOTICS, 1986, 39 (07) :1025-1027

[6]

GALE EF, 1984, MACROLIDE ANTIBIOTIC, P522

[7]

HERMANS PE, 1983, MAYO CLIN PROC, V58, P223

[8] THE ROLE OF THE CARBOXYL AND AMINO-GROUPS OF POLYENE MACROLIDES IN THEIR INTERACTIONS WITH STEROLS AND THEIR SELECTIVE TOXICITY - A P-31-NMR STUDY [J].

HERVE, M ;

DEBOUZY, JC ;

BOROWSKI, E ;

CYBULSKA, B ;

GARYBOBO, CM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 980 (03) :261-272

[9] CROSS-LINKING OF POLYMERS WITH DIMALEIMIDES [J].

KOVACIC, P ;

HEIN, RW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1959, 81 (05) :1187-1190

[10] LONG-TERM AMPHOTERICIN-B THERAPY FOR DISSEMINATED HISTOPLASMOSIS IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) [J].

MCKINSEY, DS ;

GUPTA, MR ;

RIDDLER, SA ;

DRIKS, MR ;

SMITH, DL ;

KURTIN, PJ .

ANNALS OF INTERNAL MEDICINE, 1989, 111 (08) :655-659

← 1 2 →