O-GicNAcylation: the sweet side of the cancer

被引：109

作者：

de Queirozl, Rafaela Muniz ^{[1
]}

Carvalho, Erika ^{[2
]}

Dias, Wagner Barbosa ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Ctr Ciencias Saude, Lab Glicobiol Estrutural & Func, Bloco G,Ave Carlos Chagas Filho 373,Bloco D, BR-21941902 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Bioquim Med, Rio De Janeiro, Brazil

来源：

FRONTIERS IN ONCOLOGY | 2014年 / 4卷

关键词：

O-GIcNAc; O-GIcNAcylation; cancer; review; tumorigenesis; metabolism; tumor biology; metastasis;

D O I：

10.3389/fonc.2014.00132

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

O-GIcNAcylation is an O-linked beta-N-acetylglucosamine (O-GIcNAc) moiety linked to the serine or threonine residues in proteins. O-GIcNAcylation is a dynamic post -translational modification involved in a wide range of biological processes and diseases such as cancer. This modification can increase and decrease the activity of enzymes as well as interfere with protein stability and interaction. The modulatory capacity of O-GIcNAcylation, as well as protein phosphorylation, is of paramount importance in the regulation of metabolism and intracellular signaling of tumor cells. Thus, understanding the regulation of O-GIcNAcylation in tumor cells and their difference compared to non -tumor cells may elucidate new mechanisms related to tumor generation and development, could provide a new marker to diagnosis and prognosis in patients with cancer and indicate a new target to cancer chemotherapy.

引用

页数：10

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