STUDIES ON THE TOTAL SYNTHESIS OF STREPTOGRAMIN ANTI-BIOTICS - GRISEOVIRIDIN AND MADUMYCIN (A-2315A)

被引：24

作者：

MEYERS, AI

LAWSON, J

AMOS, RA

WALKER, DG

SPOHN, RF

机构：

[1] Department of Chemistry, Colorado State University, Fort Collins

来源：

PURE AND APPLIED CHEMISTRY | 1982年 / 54卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1351/pac198254122537

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convergent synthesis of the macrocyclic anti-biotics Madumycin II (A-2315A) 1 and Griseovi ridi n 2 is in progress. Al 1 of the stereochemical centers and functional groups have been incorporated with the former obtained as pure enantiomers. The routes, pitfalls, and strategy leading to the main synthetic fragments are disclosed. All that remains to complete the synthesis is the joining together of the two major units (5, 6, and 7 ). © 2013, Walter de Gruyter. All rights reserved.

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页码：2537 / 2544

页数：8

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