STRIATAL D-2 DOPAMINE-RECEPTOR BINDING CHARACTERISTICS IN-VIVO IN PATIENTS WITH ALCOHOL DEPENDENCE

被引:202
作者
HIETALA, J
WEST, C
SYVALAHTI, E
NAGREN, K
LEHIKOINEN, P
SONNINEN, P
RUOTSALAINEN, U
机构
[1] UNIV TURKU,CTR CYCLOTRON PET,TURKU,FINLAND
[2] TURKU UNIV HOSP,DEPT RADIOL,SF-20520 TURKU,FINLAND
关键词
ALCOHOL DEPENDENCE; DOPAMINE D-2 RECEPTOR; POSITRON EMISSION TOMOGRAPHY; C-11] RACLOPRIDE;
D O I
10.1007/BF02245330
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Striatal D-2 dopamine receptor characteristics of nine male patients with alcohol dependence abstinent for 1-68 weeks and eight healthy male volunteers were studied in vivo with positron emission tomography. The selective D-2 receptor ligand [C-11]raclopride and equilibrium model was used for D-2 receptor density (B-max) and affinity (K-d) measurements. A trend for a decreased striatal D-2 receptor density and for reduced D-2 receptor affinity was observed in patients with alcohol dependence. These parameters were not statistically significantly different between alcoholics and controls, but the ratio between D-2 receptor density and affinity (B-max/K-d or the striatum/cerebellum ratio from the high specific activity scan) was highly significantly lower in alcoholics than that of controls. In conclusion, the low D-2 dopamine receptor B-max/K-d ratio (striatum/cerebellum ratio) indicates that specific aspects of striatal [C-11]raclopride binding in vivo are deviant in alcoholics compared to controls. The result is compatible with a reduced avidity of striatal dopamine D-2 receptors in alcoholics, which is in line with the idea that D-2 dopaminergic mechanisms are involved in the biology of alcohol dependence in man.
引用
收藏
页码:285 / 290
页数:6
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