Peripheral stimulation in treating Parkinson's disease: Is it a realistic idea or a romantic whimsicality?

被引：11
作者：
Asakawa, Tetsuya [1 ]
Fang, Huan [2 ]
Hong, Zhen [3 ]
Sugiyama, Kenji [1 ]
Nozaki, Takao [1 ]
Namba, Hiroki [1 ]
机构：
[1] Hamamatsu Univ Sch Med, Dept Neurosurg, Hamamatsu, Shizuoka, Japan
[2] Fudan Univ, Jinshan Hosp, Dept Pharm, Shanghai, Peoples R China
[3] Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai, Peoples R China
来源：
INTRACTABLE & RARE DISEASES RESEARCH | 2012年 / 1卷 / 04期
基金：
日本学术振兴会;
关键词：
Parkinson's disease; deep brain stimulation; peripheral stimulation; dorsal column; acupuncture; somatosensory system;
D O I：
10.5582/irdr.2012.v1.4.144
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Parkinson's disease (PD) is a common, however, intractable neurodegenerative disorder in the aging population. Levodopa (L-dopa) administration is regarded as the most effective strategy in treating PD with prominent motor side-effects after undergoing long-term treatment. Surgical therapies such as deep brain stimulation (DBS) show certain efficacy, yet there are several limitations in adopting such surgical procedures. Therefore, performing electrical stimulation out of the brain, namely peripheral stimulation for PD has been a dream of many clinicians. Recently, the efficacy of dorsal column stimulation was verified in animal PD models; on the other hand, tons of acupunctural studies from East Asia claim good efficacy in treating PD both in bench and clinical studies. This review will introduce the progress of peripheral stimulation for PD, and will discuss the potential mechanisms involved in these strategies.
引用
收藏
页码：144 / 150
页数：7
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