IMPAIRED NOCTURNAL SECRETION OF MELATONIN IN CORONARY HEART-DISEASE

被引：180

作者：

BRUGGER, P

MARKTL, W

HEROLD, M

机构：

[1] UNIV VIENNA, DEPT PHYSIOL, VIENNA, AUSTRIA

[2] UNIV INNSBRUCK, DEPT INTERNAL MED, A-6020 INNSBRUCK, AUSTRIA

来源：

LANCET | 1995年 / 345卷 / 8962期

关键词：

D O I：

10.1016/S0140-6736(95)92600-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with coronary heart disease have increased nocturnal urinary noradrenaline. Because melatonin suppresses sympathetic activity, we measured serum melatonin concentrations at night (0200 h) in 15 patients with coronary heart disease. Melatonin was significantly lower in the patients than in 10 healthy controls (median 7.8 [interquartile range 6.5-11.8] vs 36.2 [32.2-42.5] pg/mL, p<0.0001). Thus, impaired nocturnal secretion of melatonin is associated with coronary heart disease. Patients disease nocturnal noradrenaline.

引用

页码：1408 / 1408

页数：1

共 9 条

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