Effect of continuous positive airway pressure on proteinuria in obstructive sleep apnea

被引：5

作者：

Masuda, Takahiro ^{[1
,2
]}

Honma, Sumiko ^{[1
]}

Sasaki, Nobuhiro ^{[1
,2
]}

Hanawa-Yazawa, Shiho ^{[1
,2
]}

Iwazu, Yoshitaka ^{[2
]}

Kusano, Eiji ^{[2
]}

Asano, Yasushi ^{[1
]}

机构：

[1] Japanese Red Cross Koga Hosp, Dept Nephrol, Koga, Ibaraki, Japan

[2] Jichi Med Univ, Dept Med, Div Nephrol, Shimotsuke, Tochigi, Japan

来源：

CLINICAL KIDNEY JOURNAL | 2012年 / 5卷 / 03期

关键词：

continuous positive airway pressure; obstructive sleep apnea; proteinuria; renal hypoxia;

D O I：

10.1093/ckj/sfs046

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Obstructive sleep apnea (OSA) is common in patients with renal disease, and an association between OSA and proteinuria has been proposed. However, the effect on proteinuria of OSA treatment with continuous positive airway pressure (CPAP) is unknown. We experienced a case of severe OSA, where proteinuria was clearly improved after CPAP initiation without any changes of medication or body weight. The remarkable reduction of repetitive apnea and hypopnea by CPAP might ameliorate proteinuria by lessening renal hypoxia and sympathetic nerve activation. This case suggests that CPAP is a promising option for OSA with proteinuria.

引用

页码：257 / 260

页数：4

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