Bioinformatics insights into acute lung injury/acute respiratory distress syndrome

被引：26

作者：

Fang, Xiaocong ^{[1
]}

Bai, Chunxue ^{[1
]}

Wang, Xiangdong ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Dept Pulm Med, Shanghai, Peoples R China

[2] Fudan Univ, Zhongshan Hosp, Biomed Res Ctr, Shanghai, Peoples R China

[3] Lund Univ, Inst Clin Sci, Lund, Sweden

来源：

CLINICAL AND TRANSLATIONAL MEDICINE | 2012年 / 1卷

关键词：

Acute lung injury; Acute respiratory distress syndrome; Genomics; Proteomics; Metabolomics; Bioinformatics;

D O I：

10.1186/2001-1326-1-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bioinformatics is the application of omics science, information technology, mathematics and statistics in the field of biomarker detection. Clinical bioinformatics can be applied for identification and validation of new biomarkers to improve current methods of monitoring disease activity and identify new therapeutic targets. Acute lung injurt (ALI)/Acute respiratory distress syndrome (ARDS) affects a large number of patients with a poor prognosis. The present review mainly focused on the progress in understanding disease heterogeneity through the use of evolving biological, genomic, and genetic approaches and the role of clinical bioinformatics in the pathogenesis and treatment of ALI/ARDS. The remarkable advances in clinical bioinformatics can be a new way for understanding disease pathogenesis, diagnosis and treatment.

引用

页数：9

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