FPG AND UVRA PROTEINS PARTICIPATE IN THE REPAIR OF DNA LESIONS INDUCED BY HYDROGEN-PEROXIDE IN LOW IRON LEVEL IN ESCHERICHIA-COLI

被引：16

作者：

ASAD, NR

DEALMEIDA, CEB

ASAD, LMBO

FELZENSZWALB, I

LEITAO, AC

机构：

[1] FED UNIV RIO DE JANEIRO,INST BIOFIS CARLOS CHAGAS FILHO,RADIOBIOL MOLEC LAB,BR-21949900 RIO JANEIRO,BRAZIL

[2] UNIV ESTADO RIO DE JANEIRO,INST BIOL,DEPT BIOFIS & BIOMETRIA,BR-20551030 RIO JANEIRO,BRAZIL

来源：

BIOCHIMIE | 1995年 / 77卷 / 04期

关键词：

H2O2; DNA LESIONS; ESCHERICHIA COLI; LOW IRON LEVEL; FPG AND UVRA PROTEINS;

D O I：

10.1016/0300-9084(96)88134-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The survival of different DNA repair mutant strains of Escherichia coli treated with H2O2 was evaluated in the presence or absence of an iron chelator (dipyridyl). Our results suggest that Fpg and UvrA proteins participate in vivo in the repair of DNA lesions produced by higher H2O2 concentrations in the presence of an iron chelator while UvrB and UvrC proteins seem to be ineffective in the repair of these lesions.

引用

页码：262 / 264

页数：3

共 15 条

[1] EFFECTS OF METAL-ION CHELATORS ON DNA STRAND BREAKS AND INACTIVATION PRODUCED BY HYDROGEN-PEROXIDE IN ESCHERICHIA-COLI - DETECTION OF IRON-INDEPENDENT LESIONS [J].