NITRIC-OXIDE SYNTHASE ACTIVITIES IN HUMAN MYOCARDIUM

被引：323

作者：

DEBELDER, AJ

RADOMSKI, MW

WHY, HJF

RICHARDSON, PJ

BUCKNALL, CA

SALAS, E

MARTIN, JF

MONCADA, S

机构：

[1] WELLCOME RES LABS,LANGLEY COURT,BECKENHAM BR3 3BS,KENT,ENGLAND

[2] UNIV LONDON KINGS COLL HOSP,DEPT CARDIOL,LONDON SE5 8RX,ENGLAND

[3] UNIV LONDON KINGS COLL,SCH MED & DENT,DEPT MED,LONDON WC2R 2LS,ENGLAND

来源：

LANCET | 1993年 / 341卷 / 8837期

基金：

芬兰科学院;

关键词：

D O I：

10.1016/0140-6736(93)92559-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myocardial constitutive and inducible nitric oxide (NO) synthase activities were measured in right ventricular tissue from 17 patients with dilated cardiomyopathy (DCM). A significant activity of inducible enzyme was accompanied by a low activity of the constitutive NO synthase. Thus, the myocardium has the capacity to express both NO synthases. NO may have a physiological as well as a pathological role in the human myocardium.

引用

页码：84 / 85

页数：2

共 8 条

[1]

MONCADA S, 1991, PHARMACOL REV, V43, P109

[2] PATHOLOGY OF CARDIOMYOPATHIES - CRITICAL ANALYSIS [J].