THE MAP KINASE CASCADE IS ESSENTIAL FOR DIVERSE SIGNAL TRANSDUCTION PATHWAYS

被引：1036
作者：
NISHIDA, E
GOTOH, Y
机构：
[1] Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Hongo, Tokyo
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 04期
关键词：
D O I：
10.1016/0968-0004(93)90019-J
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitogen-activated protein (MAP) kinases are activated by combined tyrosine and threonine phosphorylation catalysed by MAP kinase kinase, a novel class of protein kinases with dual specificity for both tyrosine and serine/threonine. MAP kinase kinase is turned on by serine/threonine phosphorylation catalysed by an immediate upstream kinase. The MAP kinase cascade appears to be conserved during evolution and thus might play an essential role in diverse intracellular signaling processes from yeasts to vertebrates.
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页码：128 / 131
页数：4
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