X-RAY ANALYSES OF PEPTIDE-INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS

被引：127
作者：
DHANARAJ, V
DEALWIS, CG
FRAZAO, C
BADASSO, M
SIBANDA, BL
TICKLE, IJ
COOPER, JB
DRIESSEN, HPC
NEWMAN, M
AGUILAR, C
WOOD, SP
BLUNDELL, TL
HOBART, PM
GEOGHEGAN, KF
AMMIRATI, MJ
DANLEY, DE
OCONNOR, BA
HOOVER, DJ
机构：
[1] UNIV LONDON BIRKBECK COLL,MOLEC BIOL LAB,LONDON WC1E 7HX,ENGLAND
[2] UNIV LONDON BIRKBECK COLL,DEPT CRYSTALLOG,IMPERIAL CANC RES FUND,STRUCT MOLEC BIOL UNIT,LONDON WC1E 7HX,ENGLAND
[3] PFIZER INC,DEPT MOLEC GENET & PROT CHEM,GROTON,CT 06340
[4] PFIZER INC,DEPT MED CHEM,DIV CENT RES,GROTON,CT 06340
来源：
NATURE | 1992年 / 357卷 / 6378期
关键词：
D O I：
10.1038/357466a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
X-ray analyses have defined the three-dimensional structures of crystals of mouse and human renins complexed with peptide inhibitors at resolutions of 1.9 and 2.8 angstrom, respectively. The exquisite specificity of renin arises partly from ordered loop regions at the periphery of the binding cleft. Although the pattern of main-chain hydrogen bonding in other aspartic proteinase inhibitor complexes is conserved in renins, differences in the positions of secondary structure elements (particularly helices) also lead to improved specificity in renins for angiotensinogen substrates.
引用
收藏
页码：466 / 472
页数：7
相关论文
共 36 条
[21]   CRYSTALLIZATION OF MOUSE SUB-MAXILLARY GLAND RENIN [J].
MORNON, JP ;
SURCOUF, E ;
BERTHOU, J ;
CORVOL, P ;
FOOTE, S .
JOURNAL OF MOLECULAR BIOLOGY, 1982, 155 (04) :539-540
[22]  
NAVIA MA, 1984, J BIOL CHEM, V259, P2714
[23]  
NEWMAN M, 1991, J MOL BIOL, V221, P1295, DOI 10.1016/0022-2836(91)80127-G
[24]   RENIN CLEAVAGE OF A HUMAN-KIDNEY RENIN SUBSTRATE ANALOGOUS TO HUMAN ANGIOTENSINOGEN, H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-SER-OH, THAT IS HUMAN RENIN SPECIFIC AND IS RESISTANT TO CATHEPSIN-D [J].
POE, M ;
WU, JK ;
LIN, TY ;
HOOGSTEEN, K ;
BULL, HG ;
SLATER, EE .
ANALYTICAL BIOCHEMISTRY, 1984, 140 (02) :459-467
[25]   THE CRYSTAL-STRUCTURES OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION-STATE ANALOG INHIBITOR [J].
RAHUEL, J ;
PRIESTLE, JP ;
GRUTTER, MG .
JOURNAL OF STRUCTURAL BIOLOGY, 1991, 107 (03) :227-236
[26]   IMPROVED FOURIER COEFFICIENTS FOR MAPS USING PHASES FROM PARTIAL STRUCTURES WITH ERRORS [J].
READ, RJ .
ACTA CRYSTALLOGRAPHICA SECTION A, 1986, 42 :140-149
[27]   HIGH-RESOLUTION X-RAY-DIFFRACTION STUDY OF THE COMPLEX BETWEEN ENDOTHIAPEPSIN AND AN OLIGOPEPTIDE INHIBITOR - THE ANALYSIS OF THE INHIBITOR BINDING AND DESCRIPTION OF THE RIGID BODY SHIFT IN THE ENZYME [J].
SALI, A ;
VEERAPANDIAN, B ;
COOPER, JB ;
FOUNDLING, SI ;
HOOVER, DJ ;
BLUNDELL, TL .
EMBO JOURNAL, 1989, 8 (08) :2179-2188
[28]   DOMAIN FLEXIBILITY IN ASPARTIC PROTEINASES [J].
SALI, A ;
VEERAPANDIAN, B ;
COOPER, JB ;
MOSS, DS ;
HOFMANN, T ;
BLUNDELL, TL .
PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1992, 12 (02) :158-170
[29]   ON SIZE OF ACTIVE SITE IN PROTEASES .I. PAPAIN [J].
SCHECHTER, I ;
BERGER, A .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1967, 27 (02) :157-+
[30]   COMPUTER-GRAPHICS MODELING OF HUMAN RENIN - SPECIFICITY, CATALYTIC ACTIVITY AND INTRON-EXON JUNCTIONS [J].
SIBANDA, BL ;
BLUNDELL, T ;
HOBART, PM ;
FOGLIANO, M ;
BINDRA, JS ;
DOMINY, BW ;
CHIRGWIN, JM .
FEBS LETTERS, 1984, 174 (01) :102-111
1234