ONLINE RECOVERY OF TRIMEPRAZINE ENANTIOMERS FOLLOWING CHIRAL SEPARATION BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING A BETA-CYCLODEXTRIN-CONTAINING MOBILE PHASE

被引：15

作者：

COOPER, AD ^{[1
]}

JEFFERIES, TM ^{[1
]}

机构：

[1] UNIV BATH,SCH PHARM & PHARMACOL,CLAVERTON DOWN,BATH BA2 7AY,AVON,ENGLAND

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1990年 / 8卷 / 8-12期

关键词：

CHIRAL SEPARATION; CYCLODEXTRIN; SEMIPREPARATIVE HPLC; TRIMEPRAZINE;

D O I：

10.1016/0731-7085(90)80131-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A procedure is described which allows the on-line recovery of enantiomers following semi-preparative chiral separation by RP-HPLC using beta-cyclodextrin in the mobile phase. By this method, the phenothiazine antihistamine trimeprazine (I) was resolved into its antipodes at greater than 95% optical purity at a throughout of more than 1 mg of each enantiomer per hour, using 4 mm i.d. columns. The recovered trimeprazine was found to be free from cyclodextrin.

引用

页码：847 / 851

页数：5

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