T4 GENE 32 PROTEIN MODEL FOR CONTROL OF ACTIVITY OF REPLICATION FORK

被引：68

作者：

MOISE, H ^{[1
]}

HOSODA, J ^{[1
]}

机构：

[1] UNIV CALIF, SPACE SCI LAB, BERKELEY, CA 94720 USA

来源：

NATURE | 1976年 / 259卷 / 5543期

关键词：

D O I：

10.1038/259455a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Limited hydrolysis of gene 32 protein [of bacteriophage T4] by various proteinases results in the production of 3 stable cleavage products. Two of these products show an affinity for native T4 DNA cellulose that the uncleaved protein does not exhibit. A model for proteolytic cleavage and for the local unwinding of DNA in advance of the replication fork is discussed in terms of this unusual binding affinity.

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页码：455 / 458

页数：4

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