The physiological roles of secretin and its receptor

被引：71

作者：

Afroze, Syeda ^{[1
]}

Meng, Fanyin ^{[1
,2
,3
]}

Jensen, Kendal ^{[1
]}

McDaniel, Kelly ^{[2
]}

Rahal, Kinan ^{[1
]}

Onori, Paolo ^{[4
]}

Gaudio, Eugenio ^{[5
]}

Alpini, Gianfranco ^{[1
,2
,3
]}

Glaser, Shannon S. ^{[1
,2
,3
]}

机构：

[1] Texas A & M Hlth Sci Ctr, Coll Med, Dept Med, Div Gastroenterol, Temple, TX 76504 USA

[2] Texas A & M Hlth Sci Ctr, Cent Texas Vet Hlth Care Syst, Coll Med, Temple, TX 76504 USA

[3] Texas A & M Hlth Sci Ctr, Scott & White Digest Dis Res Ctr, Coll Med, Temple, TX 76504 USA

[4] Univ LAquila, Expt Med, Laquila, Italy

[5] Univ Sapienza, Dept Anat Histol Forens Med & Orthoped Sci, Rome, Italy

来源：

ANNALS OF TRANSLATIONAL MEDICINE | 2013年 / 1卷 / 03期

关键词：

Secretin; Secretin receptors;

D O I：

10.3978/j.issn.2305-5839.2012.12.01

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Secretin is secreted by S cells in the small intestine and affects the function of a number of organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several cell types. In addition to regulating the secretion of a number of epithelia (e.g., in the pancreas and biliary epithelium in the liver), secretin exerts trophic effects in several cell types. In this article, we will provide a comprehensive review on the multiple roles of secretin and SR signaling in the regulation of epithelial functions in various organ systems with particular emphasis in the liver. We will discuss the role of secretin and its receptor in health and biliary disease pathogenesis. Finally, we propose future areas of research for the further evaluation of the secretin/secretin receptor axis in liver pathophysiology.

引用

页数：14

共 134 条

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