BLOOD-BRAIN-BARRIER DISTURBANCE FOLLOWING LOCALIZED HYPERTHERMIA IN RATS

被引：22

作者：

URAKAWA, M

YAMAGUCHI, K

TSUCHIDA, E

KASHIWAGI, S

ITO, H

MATSUDA, T

机构：

[1] YAMAGUCHI UNIV, SCH MED, INST LAB ANIM, UBE, YAMAGUCHI 755, JAPAN

[2] TAMA NANBU REG HOSP, TAMA, JAPAN

来源：

INTERNATIONAL JOURNAL OF HYPERTHERMIA | 1995年 / 11卷 / 05期

关键词：

BLOOD-BRAIN BARRIER; HYPERTHERMIA; HRP; ELECTRON MICROSCOPY; PERMEABILITY;

D O I：

10.3109/02656739509022502

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the morphological effect of hyperthermia on the blood-brain barrier (BBB). The heads of rats were heated locally using hood-lamps, BBB changes were assessed morphologically with horseradish peroxidase (HRP). Histological examinations were carried out 2 and 6 h, 1 and 3 days, and 1 week after the hyperthermia. The acute thermal lesions had three zones, i.e. a necrotic zone, a reactive zone and a permeable zone of viable brain tissue. HRP extravasation was seen in the necrotic zone and the permeable zone. Electron micrographic observation revealed HRP had entered the CNS through damaged endothelial cells and disruption of the tight junctions in the necrotic zone, and through numerous pinocytotic vesicles in the permeable zone. BBB opening to HRP was observed from 6 h to 3 days after hyperthermia.

引用

页码：709 / 718

页数：10

共 23 条

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